Space Biosciences History

Flight History

Table 1: CCM Flight History

Mission #	Module #	Vehicle	Mission Duration	Launch Date	Experiment
STS-45	STL-01	Atlantis	9 days	March 1992	L8 cells
STS-53	STL-02	Discovery	7 days	December 1992	L8 cells
STS-56	STL-03	Discovery	9 days	April 1993	L8 cells
STS-59	STL/NIH.C1	Endeavour	11 days	April 1994	Rat osteoblasts, chick osteoblasts, rat skeletal muscle
STS-66	STL/NIH.C2	Atlantis	11 days	November 1994	mesenchymal cells, skeletal myoblasts, stem cells
STS-63	STL/NIH.C3	Discovery	8 days	February 1995	chick osteoblasts, L8 cells, rat osteoblasts
STS-69	STL/NIH.C4	Endeavour	10+ days	August 1995	ROS cells, HFOB cells, stem cells
STS-72	STL/NIH.C5	Endeavour	9 days	January 1996	mesenchymal cells, skeletal myoblasts
STS-77	STL/NIH.C7	Endeavour	10 days	May 1996	mesenchymal cells, skeletal myoblasts
STS-80	CCM/NIH.C6	Endeavour	17+ days	November 1996	ROS cells, HFOB cells
STS-86	CCM/01	Atlantis	10+ days	September 1997	L8 cells, BAEC cells
STS-95	CCM/NIH.C8	Discovery	9 days	October 1998	Chick cartilage, SHE, AT2KY, HCT116, HL60, MCF7, m5S
STS-93	CCM-C/02	Columbia	5 days	July 1999	C6 cells, elastin heterografts

Table 2: STL-B Flight History

Mission #	Module #	Vehicle	Mission Duration	Launch Date	Experiment
STS-59	STLB-01	Endeavour	11 days	April 1994	Medaka fish embryos
STS-70	STLB-02	Discovery	8 days	July 1995	Medaka fish embryos
STS-78	STLB-03	Columbia	17 days	June 1996	Medaka fish embryos
STS-93	STLB-04	Columbia	5 days	July 1999	Fern gametophytes

Papers Published

Reece J, Miller M, Arnold M, Waterhouse C, Cohn L, Delaplaine E, Cannon T. Continuous Oxygen Monitoring of Mammalian Cell Growth on Space Shuttle Mission STS-93 with a Novel Radioluminescent Oxygen Sensor. Applied Biochemistry and Biotechnology (in press).

Semov A, Semova N, Lacelle C, Marcotte R, Petroulakis E, Proestou G, Wang E. Alterations in TNF- and IL-related gene expression in space-flown WI38 human fibroblasts. FASEB J. 2002 Jun;16(8):899-901.

K. Ishizaki, K. Nishizawa, T. Kato, H. Kitao, Z-B. Han, J. Hirayama, F. Suzuki, T.F. Cannon, S. Kamigaichi, T. Shimazu, M. Ikenaga. Genetic Changes Induced in Human Cells in Space Shuttle Experiment (STS-95). Aviation, Space, and Environmental Medicine. 2001 Sept;72(9):794-798.

Vandenburg H, Chromiak J. Shansky J., Del Tatto M, Lemaire J., Space travel directly induces skeletal muscle atrophy. FASEB J. 1999 Jun;13(9):1031-8.

Chromiak JA, Shansky J, Perrone C, Vandenburgh HH. Bioreactor perfusion system for the long-term maintenance of tissue-engineered skeletal muscle organoids. In Vitro Cell Dev Biol Anim. 1998 Oct;34(9):694-703.

Kulesh DA, Anderson L.H, Wilson B., Otis EJ, Eglin DM, Barker MJ, Mehm WJ, Kearney GP. Space shuttle flight (STS-45) of L8 myoblast cells results in the isolation of a nonfusing cell line variant. J Cell Biochem. 1994 Aug;55(4):530-44.

Davis TA, Wiesmann W, Kidwell W, Cannon T, Kerns L, Serke C, Delaplaine T, Pranger A, Lee KP. Effect of spaceflight on human stem cell hematopoiesis: supression of erythropoiesis and myelopoiesis. J Leukoc Biol. 1996 Jul;60(1):69-76.

Landis WJ, Hodgens KJ, Block D, Toma CD, Gerstenfeld LC. Spaceflight Effects on cultured embryonic chick bone cells. J Bone Miner Res. In press.

Phillips C.R., Wolgemuth D.J., Cannon T, Pranger A, Wiesmann W.P. STL-B: A New Design to Study Embryonic Development in Microgravity. ASGSB Bulletin. October 1994.

Wiesmann W.P., Pranger L.A., Delaplaine E.S., Cannon T. Advanced Bioreactors with Optical Sensors Enable Remote Operation of Cell Biology Experiments in Space. AIAA Conference on Space Life Sciences. September 1994.

Wolgemuth D.J., et. al. Vertebrate Development in the Environment of Space: Models, Mechanisms, and Use of the Medaka. Gravitational and Space Biology Bulletin. Jun;10(2):97-109.